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Rank the most well-adapted cancer treatments
CureMatch provides a scored and ranked listing of the most well-adapted personalized medicine treatment options. The comprehensive analysis considers commonly used treatments, as well as targeted therapy, immunotherapy, hormone therapy, and newly approved oncology drugs. These options are presented either alone (monotherapy) or in combinations of up to 4 drugs.
Filter out therapies that are expected to have poor outcomes
Many cancer treatments are ineffective and can lead to drug resistance, added cost, and side-effects. CureMatch can rank therapies against its databases of genes, pathways, and drug characteristics to predict which therapies are associated with improved outcomes.
Input your own combination therapy options
Combination therapy has been used widely to treat other diseases such as HIV/AIDS, and recent studies have shown it to be effective in cancer. However, its adoption has been limited in cancer in a large part due to its complexity. CureMatch helps you see where your own proposed combinations rank alongside other highly ranked options.
Performs the multi-parametric analyses required to analyze millions of combination options.
Platform incorporates custom curated databases of publications, clinical trials, genes, pathways, and drug characteristics.
Looks at a patient’s mutations together rather than individually, such that it can analyze options that target multiple mutations rather than single drug therapies targeting individual mutations.
Integration spans many types of biological data.
Agnostic to tumor profiling company data.
The CureMatch approach has been used on thousands of patients since its initial development at the UC San Diego Moores Cancer Center and San Diego Supercomputer Center. Some recent Case Studies are provided.
The CureMatch approach has been built upon a foundation of discoveries in oncology, genomics, molecular biology, and many other cross-disciplinary fields. Key Publications are provided.
"CureMatch offers a superior genomic matching product including customized combination therapy options for informing treatment choices. The numerical score values are a powerful way to help one choose amongst possible clinical interventions."
Most cancers harbor a cocktail of genomic alterations or mutations. Personalized medicine has typically focused on targeting what the oncologist considers to be the most important mutation, using a single “targeted” drug.
CureMatch is unique in that it looks at all of a patient’s mutations together rather than individually. This enables drug combination recommendations targeting multiple mutations rather than single drug therapies.
CureMatch also integrates multiple types of biological results (DNA sequencing, protein expression, etc.) into its comprehensive analysis, and considers commonly-used cancer treatments as well all of the latest advances in cancer care, including immunotherapy, targeted therapy, hormone therapy, and newly approved cancer drugs.
The resulting analysis ranks the top 2-, 3-, and 4- drug combinations (out of more than 4.5 million options) that are customized for each individual patient.
The analysis is not a substitute for a physician’s decision, but rather it empowers the physician to make the most informed decision, using the most advanced personalized treatment options. The clear analysis layout and ranking is designed to provide actionable knowledge and insight to the oncologist.