For Patients

HARNESSING THE POWER OF PERSONALIZED MEDICINE

Cancer is a truly personal disease, with two patients rarely having the same response to identical treatments due to the genetic variation of an individual’s tumor. Until recently, cancer treatment was mainly focused on fighting a type or origin of cancer. With the introduction of personalized medicine, doctors can employ molecular profiling techniques, such as next generation NDA sequencing, to identify mutations inside each patient's tumor.

CureMatch Empowers your Oncologist to use Personalized Medicine

Unfortunately, only 2% of cancer patients today use personalized medicine to treat their cancer. This is mainly because there is just too much information for the oncologist to process and use.

CureMatch guides oncologists in the selection of personalized cancer treatment options, using supercomputing and the latest discoveries in genomics and proteomics. CureMatch analyzes the top cancer treatments for each patient, based on the molecular profile of their tumor cells, and provides a report with a ranked list of customized treatment options.

The latest advances in cancer care are considered in the analysis, including combination therapy, immunotherapy, targeted therapy, hormone therapy, and newly-approved cancer drugs.

A short video explanation

PERSONALIZED COMBINATION THERAPY™ FOR CANCER

Combination therapy has been widely used for treatment and/or prevention of other diseases, such as infectious diseases, cardiovascular diseases, diabetes, and Alzheimer’s disease, and has proven to be particularly effective for the treatment of HIV/AIDS.

Until now, combination therapy has not been not widely available for oncology, primarily because there are millions of possible drug combinations which are difficult for oncologists and tumor boards to analyze.

CureMatch is the only company to guide oncologists in the selection of Personalized Combination Therapy™, in which combinations of drugs are selected that target each of the patient's tumor mutations.

The Future of Cancer Treatment is Here

How it Works

Step One

Tissue/Liquid Biopsy

Step Two

Tumor Profiling Sequencing

Step Three

CureMatch Analysis/Ranking

Step Four

Report Sent to Doctor

Step Five

Begin Personalized Treatment

CureMatch uses a personalized approach to cancer treatment; therefore tumor profiling (such as next-generation DNA sequencing) must first be performed to identify the mutations that are specific to each individual patient’s cancer. This data is generated by taking a biopsy of the tumor or blood, and sending the sample to a third party company for processing and annotation. This is often covered by insurance.

The tumor profiling data is then provided to CureMatch, and a computational analysis is performed to rank therapies that are most likely to be successful, using CureMatch’s comprehensive set of databases and its filtering and scoring algorithms. A report is then generated and provided to the oncologist, who reviews the information and recommends a treatment plan which is personalized for the patient. The clear report layout and ranking is designed to provide concise actionable knowledge and insight. This is the latest and most advanced way to treat cancer today.

CUREMATCH PERSONALIZED COMBINATION THERAPY™ REPORT

FOR CANCER PATIENTS

$1000per report
Ranks the Top Combinations of One, Two, and Three Drugs
Considers over 300 FDA-Approved Cancer Drugs
Includes Immunotherapy and Hormone Therapy Options
Includes list of Molecular Aberrations
Includes References Relevant to each Treatment Option
Get Started

Making Sense of Precision Medicine Test Results

CureMatch Co-Founder, Dr. Razelle Kurzrock discusses Precision Medicine and Combination Therapy with Patient Power’s Andrew Schorr.

Used with permission. For more educational videos for families affected by cancer visit patientpower.info.

Why is the Current Standard of Care Not Working?

Doctors and patients have traditionally relied upon “one-size-fits-all” treatments and procedures, including chemotherapy, radiation therapy and surgery, aimed largely at fighting a particular type or origin of cancer (e.g. breast, prostate, pancreatic, etc) rather than target the unique nature of an individual patient’s cancer. This is despite one’s genotype having a profound influence on clinical responses to targeted anticancer therapies.

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In fact, patients with the same cancer diagnosis not only are unlikely to share the same specific genetic variants but also unlikely to have similar reactions to identical treatments. Thus cancer must be viewed as a personal disease, with personalized treatments to best counter the disease.

What is Personalized Medicine?

Today, doctors are able to target the unique nature of an individual patient’s tumor, by matching treatments at the molecular level; resulting in improved outcomes. A recent study conducted by the CureMatch team found that patients with advanced cancers treated using the traditional or standard of care, which is based on their type or origin of cancer rather than their molecular tumor profile, had a mere 5% response rate to their treatment.

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When patients with advanced cancers were treated using a personalized approach, matching them at the molecular level, there was a 27% response rate. This is personalized medicine. And it is available now.

Why Personalized Combination Therapy?

Cancer has historically been treated using standard, single-drug therapies to target specific cancers, and even when using personalized cancer therapy, the vast majority of treatments are performed using targeted monotherapies. Though far superior to standard therapies in that a tumor’s genetic mutation is matched to a specific drug therapy, monotherapies are also deficient in that it is rare that a cancerous tumor has only one mutation that requires a matching therapy. Recently, it has been shown that when the right combination of multiple drugs is used to match multiple mutations, cancer treatment is more effective.

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Each drug is able to target individual cancer mutations to improve treatment, and each drug can be used with the right dose to reduce side effects. Until now, matched combination therapy was not available outside of research, mainly because there are millions of possible drug combinations that are difficult for doctors to analyze. That is where CureMatch comes in. Our goal is to make matched combination therapy a clinical reality for oncologists and patients worldwide.

What is Personalized Combination Therapy?

CureMatch’s personalized combination therapy approach can be illustrated using a simple example, using cancer cell lines derived from the tumors of patients. In this example, we used cell lines from human pancreatic adenocarcinoma tumors with eight mutations, two of which were “actionable” – meaning that these two mutations were known to be responsive to a specific drug.

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Although the standard of care for this type of cancer is treatment with gemcitabine—the most commonly used chemotherapy in the treatment of pancreatic adenocarcinoma—the CureMatch platform instead recommended a combination of two specific drugs (“Drug A” and “Drug B”)* to simultaneously target the two actionable mutations.

In order to assess the efficacy of the recommended treatment, four scenarios were compared: (1) standard chemotherapy (gemcitabine); (2) personalized monotherapy using Drug A only; (3) personalized monotherapy using Drug B only; and (4) personalized combination therapy using both Drug A and B (the CureMatch-recommended therapy). A graphic representation is shown below, with the two actionable mutations shown on the DNA strands in red and green.

chart=showing-various-cancer-treatments

The effects of the drug treatments were measured using a cell viability assay, which measures the number of living cells remaining after treatment. Matched combination therapy (the CureMatch-recommended therapy), at 1:1 concentrations of Drug A:Drug B, not only resulted in a significant increase in cell death compared to the matched monotherapies (3-5 fold increase), but also in a significant increase in cell death when compared to standard chemotherapy (>20-fold increase).

This in vitro data supports the notion that combinations of drugs specifically “matched” to actionable mutations present in a patient’s tumor have the potential to provide greatly improved outcomes compared not only to standard chemotherapy but to matched monotherapy. This the basis of the CureMatch approach.

Innovation in Cancer Care

A core principle behind the CureMatch technology was selected by the American Society of Clinical Oncology (ASCO) as a major achievement in clinical cancer research and care.

ASCO recognized a recently published study by co-founder and Chief Medical Advisor, Dr. Razelle Kurzrock in Clinical Cancer Advances 2017, its annual review of progress against cancer and emerging trends in the field. More details on the study can be found here.